Syntaxin-6 SNARE involvement in secretory and endocytic pathways of cultured pancreatic beta-cells.
AuthorsKuliawat R, Kalinina E, Bock J, Fricker L, McGraw TE, Kim SR, Zhong J, Scheller R, Arvan P,
JournalMol Biol Cell
PubMed ID14742717
'In pancreatic beta-cells, the syntaxin 6 (Syn6) soluble N-ethylmaleimide-sensitive factor attachment protein receptor is distributed in the trans-Golgi network (TGN) (with spillover into immature secretory granules) and endosomes. A possible Syn6 requirement has been suggested in secretory granule biogenesis, but the role of Syn6 in live regulated secretory cells remains ... More
Deletion of the mental retardation gene Gdi1 impairs associative memory and alters social behavior in mice.
AuthorsD'Adamo P, Welzl H, Papadimitriou S, Raffaele di Barletta M, Tiveron C, Tatangelo L, Pozzi L, Chapman PF, Knevett SG, Ramsay MF, Valtorta F, Leoni C, Menegon A, Wolfer DP, Lipp HP, Toniolo D,
JournalHum Mol Genet
PubMed ID12354782
Non-specific mental retardation (NSMR) is a common human disorder characterized by mental handicap as the only clinical symptom. Among the recently identified MR genes is GDI1, which encodes alpha Gdi, one of the proteins controlling the activity of the small GTPases of the Rab family in vesicle fusion and intracellular ... More
Authors Greenfield Jeffrey P; Leung Lawrence W; Cai Dongming; Kaasik Krista; Gross Rachel S; Rodriguez-Boulan Enrique; Greengard Paul; Xu Huaxi;
JournalJ Biol Chem
PubMed ID11823458
Estrogen reduces the risk of Alzheimer's disease in post-menopausal women, beta-amyloid (Abeta) burden in animal models of Alzheimer's disease, and secretion of Abeta from neuronal cultures. The biological basis for these effects remains unknown. Here, utilizing cell-free systems derived from both neuroblastoma cells and primary neurons, we demonstrate that 17beta-estradiol ... More
EPI64 protein functions as a physiological GTPase-activating protein for Rab27 protein and regulates amylase release in rat parotid acinar cells.
AuthorsImai A, Yoshie S, Ishibashi K, Haga-Tsujimura M, Nashida T, Shimomura H, Fukuda M
JournalJ Biol Chem
PubMed ID21832089
Rab27, a small GTPase, is generally recognized as an important regulator of secretion that interacts with Rab27-specific effectors to regulate events in a wide variety of cells, including endocrine and exocrine cells. However, the mechanisms governing the spatio-temporal regulation of GTPase activity of Rab27 are not firmly established, and no ... More