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ErbB2 (HER-2) Antibody (710452) in IHC (P)
Immunohistochemical analysis of ErbB2 (HER-2) was performed using formalin-fixed paraffin-embedded human breast cancer (ER/PR/Her2 +ve) tissue sections. To expose the target protein, heat-induced epitope retrieval was performed on de-paraffinized sections using eBioscience™ IHC Antigen Retrieval Solution - High pH (10X) (Product # 00-4956-58) diluted to 1X solution in water in a decloaking chamber at 110 de... View More
产品信息
710452
应用
建议稀释比
已发表文章
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
Expression System
Expi293
分类
Recombinant Superclonal
类型
Antibody
克隆号
7HCLC
抗原
Peptide corresponding to amino acids 33-46 of human ERBB2
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
0.5 mg/mL
规格
100 µg
纯化类型
Protein A
保存液
PBS
内含物
0.09% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
产品详细信息
Recombinant rabbit Superclonal™ antibodies are unique offerings from Thermo Fisher Scientific. They are comprised of a selection of multiple different recombinant monoclonal antibodies, providing the best of both worlds - the sensitivity of polyclonal antibodies with the specificity of monoclonal antibodies - all delivered with the consistency only found in a recombinant antibody. While functionally the same as a polyclonal antibody - recognizing multiple epitope sites on the target and producing higher detection sensitivity for low abundance targets - a recombinant rabbit Superclonal™ antibody has a known mixture of light and heavy chains. The exact population can be produced in every lot, circumventing the biological variability typically associated with polyclonal antibody production. Note: Formerly called 'Recombinant polyclonal antibody', this product is now rebranded as 'Recombinant Superclonal™ antibody'. The physical product and the performance remain unchanged.
靶标信息
ErbB2 (HER2) is a receptor tyrosine kinase that is overexpressed in some breast tumors. Herceptin, used in treatment of metastatic Her2-positive cancer, is monoclonal antibody targeting this kinase.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: approximately 68 kDa secreted autoinhibitor glycoprotein; c-erb B2/neu protein; CD antigen CD340; CD340; erb-b2; erbb 2; ErbB2 (pTyr1139); ErbB2 (pY1139); ErbB2 phospho Y1139; her 2; HER2 receptor; HER2/neu receptor; herstatin; human epidermal growth factor receptor 2; metas; Metastatic lymph node gene 19 protein; MLN 19; neuro/glioblastoma derived oncogene homolog; neuroblastoma/glioblastoma derived oncogene homolog; p185erbB2; phospho ErbB2; Proto-oncogene c-ErbB-2; Proto-oncogene Neu; Receptor tyrosine-protein kinase erbB-2; Tyrosine kinase-type cell surface receptor HER2; unnamed protein product; v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2; v-erb-b2 avian erythroblastic leukemia viral oncoprotein 2; v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog
基因别名: c-ERB-2; c-ERB2; CD340; ERBB2; HER-2; HER-2/neu; HER2; MLN 19; MLN-19; MLN19; NEU; NGL; p185(erbB2); TKR1; VSCN2
UniProt ID: (Human) P04626
Entrez Gene ID: (Human) 2064
nucleotide binding
RNA polymerase I core binding
protein kinase activity
protein tyrosine kinase activity
transmembrane receptor protein tyrosine kinase activity
transmembrane signaling receptor activity
receptor binding
protein binding
ATP binding
coreceptor activity
kinase activity
transferase activity
growth factor binding
receptor tyrosine kinase binding
identical protein binding
ErbB-3 class receptor binding
protein heterodimerization activity
protein phosphorylation
signal transduction
cell surface receptor signaling pathway
enzyme linked receptor protein signaling pathway
transmembrane receptor protein tyrosine kinase signaling pathway
epidermal growth factor receptor signaling pathway
nervous system development
peripheral nervous system development
heart development
neuromuscular junction development
motor neuron axon guidance
cell proliferation
positive regulation of gene expression
Schwann cell development
peptidyl-tyrosine phosphorylation
neuron differentiation
positive regulation of cell growth
regulation of microtubule-based process
immature T cell proliferation in thymus
negative regulation of immature T cell proliferation in thymus
positive regulation of Rho protein signal transduction
intracellular signal transduction
ERBB2 signaling pathway
ERBB2-ERBB3 signaling pathway
ERBB2-EGFR signaling pathway
ERBB2-ERBB4 signaling pathway
wound healing
regulation of cell proliferation
myelination
negative regulation of apoptotic process
positive regulation of MAP kinase activity
positive regulation of MAPK cascade
protein kinase B signaling
positive regulation of translation
regulation of angiogenesis
positive regulation of cell adhesion
positive regulation of transcription from RNA polymerase I promoter
oligodendrocyte differentiation
positive regulation of epithelial cell proliferation
regulation of ERK1 and ERK2 cascade
cellular response to growth factor stimulus
cellular response to epidermal growth factor stimulus
semaphorin-plexin signaling pathway
positive regulation of protein targeting to membrane
neurotransmitter receptor localization to postsynaptic specialization membrane
positive regulation of intracellular signal transduction
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