'ESX is an epithelial-restricted member of a large family of transcription factors known as the Ets family. ESX expression has been shown to be correlated with Her2/neu proto-oncogene amplification in highly aggressive breast cancers and induced by Her2/neu in breast cell lines, but its role in tumorigenesis is unknown. Previously, ... More
Glucocorticoid receptor function in hepatocytes is essential to promote postnatal body growth.
Mice carrying a hepatocyte-specific inactivation of the glucorticoid receptor (GR) gene show a dramatic reduction in body size. Growth hormone signaling mediated by the Stat5 transcription factors is impaired. We show that Stat5 proteins physically interact with GR and GR is present in vivo on Stat5-dependent IGF-I and ALS regulatory ... More
Differential regulation of the TRAIL death receptors DR4 and DR5 by the signal recognition particle.
AuthorsRen YG, Wagner KW, Knee DA, Aza-Blanc P, Nasoff M, Deveraux QL,
JournalMol Biol Cell
PubMed ID15356269
TRAIL (TNF-related apoptosis-inducing ligand) death receptors DR4 and DR5 facilitate the selective elimination of malignant cells through the induction of apoptosis. From previous studies the regulation of the DR4 and DR5 cell-death pathways appeared similar; nevertheless in this study we screened a library of small interfering RNA (siRNA) for genes, ... More
Myofibroblast development is characterized by specific cell-cell adherens junctions.
AuthorsHinz B, Pittet P, Smith-Clerc J, Chaponnier C, Meister JJ,
JournalMol Biol Cell
PubMed ID15240821
Myofibroblasts of wound granulation tissue, in contrast to dermal fibroblasts, join stress fibers at sites of cadherin-type intercellular adherens junctions (AJs). However, the function of myofibroblast AJs, their molecular composition, and the mechanisms of their formation are largely unknown. We demonstrate that fibroblasts change cadherin expression from N-cadherin in early ... More