Role of LFA-1 and VLA-4 in the adhesion of cloned normal and LFA-1 (CD11/CD18)-deficient T cells to cultured endothelial cells. Indication for a new adhesion pathway.
AuthorsVennegoor CJ, van de Wiel-van Kemenade E, Huijbens RJ, Sanchez-Madrid F, Melief CJ, Figdor CG,
JournalJ Immunol
PubMed ID1371131
Patients with the leukocyte adhesion deficiency (LAD) syndrome have a genetic defect in the common beta 2-chain (CD18) of the leukocyte integrins. This defect can result in the absence of cell surface expression of all three members of the leukocyte integrins. We investigated the capacity of T cell clones obtained ... More