Human bile salt export pump promoter is transactivated by the farnesoid X receptor/bile acid receptor.
AuthorsAnanthanarayanan M, Balasubramanian N, Makishima M, Mangelsdorf DJ, Suchy FJ
JournalJ Biol Chem
PubMed ID11387316
'The bile salt excretory pump (BSEP, ABCb11) is critical for ATP-dependent transport of bile acids across the hepatocyte canalicular membrane and for generation of bile acid-dependent bile secretion. Recent studies have demonstrated that the expression of this transporter is sensitive to the flux of bile acids through the hepatocyte, possibly ... More
Radiation-induced epidermal growth factor receptor nuclear import is linked to activation of DNA-dependent protein kinase.
AuthorsDittmann K, Mayer C, Fehrenbacher B, Schaller M, Raju U, Milas L, Chen DJ, Kehlbach R, Rodemann HP
JournalJ Biol Chem
PubMed ID16000298
Ionizing radiation, but not stimulation with epidermal growth factor (EGF), triggers EGF receptor (EGFR) import into the nucleus in a probably karyopherin alpha-linked manner. An increase in nuclear EGFR is also observed after treatment with H2O2, heat, or cisplatin. During, this process, the proteins Ku70/80 and the protein phosphatase 1 ... More
Curcumin interrupts the interaction between the androgen receptor and Wnt/ß-catenin signaling pathway in LNCaP prostate cancer cells.
AuthorsChoi HY, Lim JE, Hong JH
JournalProstate Cancer Prostatic Dis
PubMed ID20680030
Recently, studies have investigated the significance of the Wnt/ß-catenin pathway in prostate cancer. The transcriptional activity of the androgen receptor (AR) is modulated by interaction with coregulators, one of which is ß-catenin. Curcumin, a dietary yellow pigment of Curcuma longa, has emerged as having a chemopreventive role. Although curcumin has ... More