Bcl-2 expression and frequency of apoptosis correlate with morphogenesis of colorectal neoplasia.
AuthorsSuzuki Y, Honma T, Hayashi S, Ajioka Y, Asakura H,
JournalJ Clin Pathol
PubMed ID11896074
To investigate whether the expression of apoptosis and cell proliferation related proteins is related to the macroscopic form of colorectal neoplasia. The extent of apoptosis, using the 3' end DNA labelling method, and the immunohistochemical expression of cell proliferation (Ki-67) and apoptosis related proteins (Bcl-2, Bak, and p53) were investigated ... More
Placental transmogrification of the lung is a histologic pattern frequently associated with pulmonary fibrochondromatous hamartoma.
AuthorsXu R, Murray M, Jagirdar J, Delgado Y, Melamed J,
JournalArch Pathol Lab Med
PubMed ID11958661
Placental transmogrification of the lung is a term introduced to describe a peculiar histologic pattern characterized by formation of placental villuslike structures in the lung parenchyma. It has been reported to occur in association with bullous emphysema and lipomatosis. To study the relationship between placental transmogrification and pulmonary hamartomas. Reports ... More
Induction of ribosomal genes and hepatocyte hypertrophy by adenovirus-mediated expression of c-Myc in vivo.
AuthorsKim S, Li Q, Dang CV, Lee LA,
JournalProc Natl Acad Sci U S A
PubMed ID11005843
Overexpression of c-Myc in immortalized cells increases cell proliferation, inhibits cell differentiation, and promotes cell transformation. Recent evidence suggests that these effects, however, do not necessarily occur when c-Myc is overexpressed in primary mammalian cells. We sought to determine the immediate effects of transient overexpression of c-Myc in primary cells ... More