Role of the constitutive androstane receptor in xenobiotic-induced thyroid hormone metabolism.
AuthorsQatanani M, Zhang J, Moore DD
JournalEndocrinology
PubMed ID15564320
The induction of hepatic drug metabolizing enzymes alters not only the metabolism of the xenobiotic substances that induce them but also the metabolism of various endogenous hormones. The xenobiotic receptor constitutive androstane receptor (CAR) (NR1I3) mediates the well-studied induction of CYP2B genes and other drug-metabolizing enzymes by phenobarbital (PB), an ... More