Co-transplantation of GDNF-overexpressing neural stem cells and fetal dopaminergic neurons mitigates motor symptoms in a rat model of Parkinson's disease.
AuthorsDeng X, Liang Y, Lu H, Yang Z, Liu R, Wang J, Song X, Long J, Li Y, Lei D, Feng Z
Journal
PubMed ID24312503
Striatal transplantation of dopaminergic (DA) neurons or neural stem cells (NSCs) has been reported to improve the symptoms of Parkinson's disease (PD), but the low rate of cell survival, differentiation, and integration in the host brain limits the therapeutic efficacy. We investigated the therapeutic effects of intracranial co-transplantation of mesencephalic ... More
Cyclic Nucleotide Control of Microtubule Dynamics for Axon Guidance.
AuthorsAkiyama H, Fukuda T, Tojima T, Nikolaev VO, Kamiguchi H
JournalJ Neurosci
PubMed ID27194341
'Graded distribution of intracellular second messengers, such as Ca(2+) and cyclic nucleotides, mediates directional cell migration, including axon navigational responses to extracellular guidance cues, in the developing nervous system. Elevated concentrations of cAMP or cGMP on one side of the neuronal growth cone induce its attractive or repulsive turning, respectively. ... More
TLR7-mediated skin inflammation remotely triggers chemokine expression and leukocyte accumulation in the brain.
AuthorsMcColl A, Thomson CA, Nerurkar L, Graham GJ, Cavanagh J
JournalJ Neuroinflammation
PubMed ID27160148
The relationship between the brain and the immune system has become increasingly topical as, although it is immune-specialised, the CNS is not free from the influences of the immune system. Recent data indicate that peripheral immune stimulation can significantly affect the CNS. But the mechanisms underpinning this relationship remain unclear. ... More