Amentoflavone Induces Apoptosis and Inhibits NF-?B-modulated Anti-apoptotic Signaling in Glioblastoma Cells.
AuthorsYen TH, Hsieh CL, Liu TT, Huang CS, Chen YC, Chuang YC, Lin SS, Hsu FT
Journal
PubMed ID29475910
The goal of the present study was to investigate anticancer effect of amentoflavone on glioblastoma cells in vitro. Our results demonstrated that amentoflavone not only significantly reduced cell viability, nuclear factor-?appa B (NF-?B) activation, and protein expression of cellular Fas-associated protein with death domain-like interleukin 1 beta-converting enzyme inhibitory protein ... More
Hyperforin Inhibits Cell Growth by Inducing Intrinsic and Extrinsic Apoptotic Pathways in Hepatocellular Carcinoma Cells.
AuthorsChiang IT, Chen WT, Tseng CW, Chen YC, Kuo YC, Chen BJ, Weng MC, Lin HJ, Wang WS
JournalAnticancer Res
PubMed ID28011486
'The aim of the present study was to investigate the antitumor effect and mechanism of action of hyperforin in hepatocellular carcinoma (HCC) SK-Hep1 cells in vitro. Cells were treated with different concentrations of hyperforin for different periods of time. Effects of hyperforin on cell viability, apoptosis signaling, and expression of ... More
Mechanism of Premature Apoptosis in CD1d-Restricted Natural Killier T Cells From Human Peripheral Blood During the Induction of Proliferation In Vitro.
AuthorsGao L, Fan Y, Yang Y, Xie R, Yang J, Chen Z
JournalTransplant Proc
PubMed ID29880380
'A preliminary investigation on the proliferation and cultivation process of natural killer T cells (NKT) was carried out. We provide reference data for future NKT-related research and development.' ... More
Some Ototoxic Drugs Destroy Cochlear Support Cells Before Damaging Sensory Hair Cells.
AuthorsDing D, Zhang J, Jiang H, Xuan W, Qi W, Salvi R
JournalNeurotox Res
PubMed ID31997155
'A wide variety of ototoxic drugs are capable of damaging the sensory hair cells in the mammalian cochlea resulting in permanent hearing loss. However, the toxic properties of these drugs suggest that some could potentially damage cochlear support cells as well. To test the hypothesis, we treated postnatal day three ... More
Comparison of
AuthorsOpydo-Chanek M, Sladowska K, Blicharski K, Mikeš J, Fedorocko P, Niemeyer U, Mazur L
JournalAnticancer Res
PubMed ID29061820
The oxazaphosphorines, ifosfamide and cyclophosphamide, represent a class of alkylating agents. The aim of the present in vitro study was to compare antileukemic activity of 4-hydroperoxyifosfamide (4-OOH-IF) and 4-hydroperoxycyclophosphamide (4-OOH-CP). ... More
Regorafenib Induces Apoptosis and Inhibits Metastatic Potential of Human Bladder Carcinoma Cells.
AuthorsHsu FT, Sun CC, Wu CH, Lee YJ, Chiang CH, Wang WS
JournalAnticancer Res
PubMed ID28870913
The aim of the present study was to verify the effects of regorafenib on apoptosis and metastatic potential in TSGH 8301 human bladder carcinoma cells in vitro. Cells were treated with different concentration of regorafenib for different periods of time. Effects of regorafenib on cell viability, apoptosis pathways, metastatic potential, ... More
The effects of obesity on CD47 expression in erythrocytes.
AuthorsWiewiora M, Piecuch J, Sedek L, Mazur B, Sosada K
JournalCytometry B Clin Cytom
PubMed ID25914268
To investigate the effects of obesity on CD47, phosphatidylserine (PS) exposure, and Caspase-8 and Caspase-3 activities in erythrocytes.
Caspase-1 Activity in CD4 T Cells Is Downregulated Following Antiretroviral Therapy for HIV-1 Infection.
AuthorsCai R, Liu L, Luo B, Wang J, Shen J, Shen Y, Zhang R, Chen J, Lu H
JournalAIDS Res Hum Retroviruses
PubMed ID27832707
Both Caspase 1-induced cell death and Caspase 3-induced cell death were reported to be the causes of CD4
Nonconserved miR-608 suppresses prostate cancer progression through RAC2/PAK4/LIMK1 and BCL2L1/caspase-3 pathways by targeting the 3'-UTRs of RAC2/BCL2L1 and the coding region of PAK4.
AuthorsZhang X, Fang J, Chen S, Wang W, Meng S, Liu B
JournalCancer Med
PubMed ID31389670
The aim of this study is to investigate the functions and mechanisms of miR-608 in prostate cancer (PCa). CISH and qRT-PCR analysis demonstrated that miR-608 was low expressed in PCa tissues and cells, which was partly attributed to the methylation of CpG island adjacent to the transcription start site (TSS) ... More