Curcumin induces concentration-dependent alterations in mitochondrial function through ROS in C2C12 mouse myoblasts.
AuthorsYu T, Dohl J, Elenberg F, Chen Y, Deuster P
JournalJ Cell Physiol
PubMed ID30246249
'Curcumin exhibits antioxidant properties in normal cells where the uptake is low, unlike in tumor cells where uptake is high and curcumin increases reactive oxygen species (ROS) production and cell death. Mitochondria are the main source and primary target of cellular ROS. We hypothesized that curcumin would regulate cellular redox ... More
Some Ototoxic Drugs Destroy Cochlear Support Cells Before Damaging Sensory Hair Cells.
AuthorsDing D, Zhang J, Jiang H, Xuan W, Qi W, Salvi R
JournalNeurotox Res
PubMed ID31997155
'A wide variety of ototoxic drugs are capable of damaging the sensory hair cells in the mammalian cochlea resulting in permanent hearing loss. However, the toxic properties of these drugs suggest that some could potentially damage cochlear support cells as well. To test the hypothesis, we treated postnatal day three ... More
Caspase-1 Activity in CD4 T Cells Is Downregulated Following Antiretroviral Therapy for HIV-1 Infection.
AuthorsCai R, Liu L, Luo B, Wang J, Shen J, Shen Y, Zhang R, Chen J, Lu H
JournalAIDS Res Hum Retroviruses
PubMed ID27832707
Both Caspase 1-induced cell death and Caspase 3-induced cell death were reported to be the causes of CD4