Chronic stress and elevated levels of glucocorticoids (GCs), the main stress hormones, accelerate Alzheimer's disease (AD) onset and progression. A major driver of AD progression is the spreading of pathogenic Tau protein between brain regions, precipitated by neuronal Tau secretion. While stress and high GC levels are known to induce ... More
DNA sequence-induced solid phase transition as a solution to the genome folding paradox.
AuthorsPulupa JM,McArthur NG,Stathi O,Wang M,Zazhytska M,Pirozzolo ID,Nayar A,Shapiro L,Lomvardas S
JournalResearch square
PubMed ID39678350
Ultra long-range genomic contacts, which emerge as prominent components of genome architecture, constitute a biochemical paradox. This is because regulatory DNA elements make selective and stable contacts with DNA sequences located megabases away, instead of interacting with proximal sequences occupied by the same exact transcription factors (TF). This is exemplified ... More
Noncompetitive immunoassay optimized for pharmacokinetic assessments of biologically active efruxifermin.
JournalJournal of pharmaceutical and biomedical analysis
PubMed ID37141854
Efruxifermin (EFX) is a homodimeric human IgG(1) Fc-FGF21 fusion protein undergoing investigation for treatment of liver fibrosis due to nonalcoholic steatohepatitis (NASH), a prevalent and serious metabolic disease for which there is no approved treatment. Biological activity of FGF21 requires its intact C-terminus, which enables binding to its obligate co-receptor ... More
Initial exposure to a rapidly evolving virus establishes B cell memory that biases later responses to antigenically drifted strains. This "immune imprinting" implies that subsequent exposure to a drifted strain can induce affinity maturation of memory B cells toward cross-reactivity with the drifted strain and hence toward greater overall breadth. ... More