A RNA producing DNA hydrogel as a platform for a high performance RNA interference system.
AuthorsSong J, Lee M, Kim T, Na J, Jung Y, Jung GY, Kim S, Park N
JournalNat Commun
PubMed ID30337586
RNA interference (RNAi) is a mechanism in which small interfering RNA (siRNA) silences a target gene. Herein, we describe a DNA hydrogel capable of producing siRNA and interfering with protein expression. This RNAi-exhibiting gel (termed I-gel for interfering gel) consists of a plasmid carrying the gene transcribing siRNA against the ... More
The transcription factor CBFB suppresses breast cancer through orchestrating translation and transcription.
AuthorsMalik N, Yan H, Moshkovich N, Palangat M, Yang H, Sanchez V, Cai Z, Peat TJ, Jiang S, Liu C, Lee M, Mock BA, Yuspa SH, Larson D, Wakefield LM, Huang J
JournalNat Commun
PubMed ID31061501
Translation and transcription are frequently dysregulated in cancer. These two processes are generally regulated by distinct sets of factors. The CBFB gene, which encodes a transcription factor, has recently emerged as a highly mutated driver in a variety of human cancers including breast cancer. Here we report a noncanonical role ... More