P-glycoprotein mediates drug resistance via a novel mechanism involving lysosomal sequestration.
AuthorsYamagishi T, Sahni S, Sharp DM, Arvind A, Jansson PJ, Richardson DR
Journal
PubMed ID24062304
'Localization of the drug transporter P-glycoprotein (Pgp) to the plasma membrane is thought to be the only contributor of Pgp-mediated multidrug resistance (MDR). However, very little work has focused on the contribution of Pgp expressed in intracellular organelles to drug resistance. This investigation describes an additional mechanism for understanding how ... More
Dysfunction of autophagy participates in vacuole formation and cell death in cells replicating hepatitis C virus.
AuthorsTaguwa S, Kambara H, Fujita N, Noda T, Yoshimori T, Koike K, Moriishi K, Matsuura Y
JournalJ Virol
PubMed ID21994453
Hepatitis C virus (HCV) is a major cause of chronic liver diseases. A high risk of chronicity is the major concern of HCV infection, since chronic HCV infection often leads to liver cirrhosis and hepatocellular carcinoma. Infection with the HCV genotype 1 in particular is considered a clinical risk factor ... More
ErbB2 trafficking and degradation associated with K48 and K63 polyubiquitination.
AuthorsMarx C, Held JM, Gibson BW, Benz CC
JournalCancer Res
PubMed ID20406983
The overexpressed ErbB2/HER2 receptor is a clinically validated cancer target whose surface localization and internalization mechanisms remain poorly understood. Downregulation of the overexpressed 185-kDa ErbB2 receptor is rapidly (2-6 hours) induced by the HSP90 chaperone inhibitor geldanamycin (GA), whereas its downregulation and lysosomal degradation are more slowly (24 hours) induced ... More