Protein synthesis rates and ribosome occupancies reveal determinants of translation elongation rates.
AuthorsRiba A,Di Nanni N,Mittal N,Arhné E,Schmidt A,Zavolan M
JournalProceedings of the National Academy of Sciences of the United States of America
PubMed ID31292258
Although protein synthesis dynamics has been studied both with theoretical models and by profiling ribosome footprints, the determinants of ribosome flux along open reading frames (ORFs) are not fully understood. Combining measurements of protein synthesis rate with ribosome footprinting data, we here inferred translation initiation and elongation rates for over ... More