Methylation of histone H3 by COMPASS requires ubiquitination of histone H2B by Rad6.
Authors Dover Jim; Schneider Jessica; Tawiah-Boateng Mary Anne; Wood Adam; Dean Kimberly; Johnston Mark; Shilatifard Ali;
JournalJ Biol Chem
PubMed ID12070136
'The DNA of eukaryotes is wrapped around nucleosomes and packaged into chromatin. Covalent modifications of the histone proteins that comprise the nucleosome alter chromatin structure and have major effects on gene expression. Methylation of lysine 4 of histone H3 by COMPASS is required for silencing of genes located near chromosome ... More