The origin of a developmentally regulated Igh replicon is located near the border of regulatory domains for Igh replication and expression.
Authors Zhou Jie; Ashouian Nasrin; Delepine Marc; Matsuda Fumihiko; Chevillard Christophe; Riblet Roy; Schildkraut Carl L; Birshtein Barbara K;
JournalProc Natl Acad Sci U S A
PubMed ID12370427
The 3' Ig heavy chain locus (Igh) regulatory region is the most downstream known element of the murine Igh gene cluster. We report here that the nearest non-Igh genes-Crip, Crp2, and Mta1-are located approximately 70 kb further downstream and are beyond the end of the domain of Igh transcriptional regulation. ... More
p53 regulates cell survival by inhibiting PIK3CA in squamous cell carcinomas.
Interactions between the p53 and PI3K/AKT pathways play a significant role in the determination of cell death/survival. In benign cells these pathways are interrelated through the transcriptional regulation of PTEN by p53, which is required for p53-mediated apoptosis. PTEN exerts its effects by decreasing the phosphorylated AKT fraction, thereby diminishing ... More