Mouse transferrin receptor 1 is the cell entry receptor for mouse mammary tumor virus.
Authors Ross Susan R; Schofield Jason J; Farr Christine J; Bucan Maja;
JournalProc Natl Acad Sci U S A
PubMed ID12218182
'Enveloped viruses enter cells by binding to their entry receptors and fusing with the membrane at the cell surface or after trafficking through acidic endosomal compartments. Species-specific virus tropism is usually determined by these entry receptors. Because mouse mammary tumor virus (MMTV) is unable to infect Chinese hamster cells, we ... More
Gene-expression profiles predict survival of patients with lung adenocarcinoma.
Authors Beer David G; Kardia Sharon L R; Huang Chiang-Ching; Giordano Thomas J; Levin Albert M; Misek David E; Lin Lin; Chen Guoan; Gharib Tarek G; Thomas Dafydd G; Lizyness Michelle L; Kuick Rork; Hayasaka Satoru; Taylor Jeremy M G; Iannettoni Mark D; Orringer Mark B; Hanash Samir;
JournalNat Med
PubMed ID12118244
'Histopathology is insufficient to predict disease progression and clinical outcome in lung adenocarcinoma. Here we show that gene-expression profiles based on microarray analysis can be used to predict patient survival in early-stage lung adenocarcinomas. Genes most related to survival were identified with univariate Cox analysis. Using either two equivalent but ... More
Pathfinding and error correction by retinal axons: the role of astray/robo2.
Authors Hutson Lara D; Chien Chi Bin;
JournalNeuron
PubMed ID11804561
To address how the highly stereotyped retinotectal pathway develops in zebrafish, we used fixed-tissue and time-lapse imaging to analyze morphology and behavior of wild-type and mutant retinal growth cones. Wild-type growth cones increase in complexity and pause at the midline. Intriguingly, they make occasional ipsilateral projections and other pathfinding errors, ... More
Overexpression of an ADP-ribosylation factor-guanine nucleotide exchange factor, BIG2, uncouples brefeldin A-induced adaptor protein-1 coat dissociation and membrane tubulation.
BIG2 is a guanine nucleotide exchange factor (GEF) for the ADP-ribosylation factor (ARF) family of small GTPases, which regulate membrane association of COPI and adaptor protein (AP)-1 coat protein complexes. A fungal metabolite, brefeldin A (BFA), inhibits ARF-GEFs and leads to redistribution of coat proteins from membranes to the cytoplasm ... More
Poly(ADP-ribose) polymerase-2 (PARP-2) is required for efficient base excision DNA repair in association with PARP-1 and XRCC1.
The DNA damage dependence of poly(ADP-ribose) polymerase-2 (PARP-2) activity is suggestive of its implication in genome surveillance and protection. Here we show that the PARP-2 gene, mainly expressed in actively dividing tissues follows, but to a smaller extent, that of PARP-1 during mouse development. We found that PARP-2 and PARP-1 ... More