Surrogate light chain production during B cell differentiation: differential intracellular versus cell surface expression.
AuthorsWang YH, Nomura J, Faye-Petersen OM, Cooper MD
JournalJ Immunol
PubMed ID9686571
Expression of the surrogate light (psi L) chain genes encoding the VpreB and lambda 5/14.1 proteins is restricted to B-lineage cells. Pro-B and pre-B cells produce psi L chains, but whether both employ these as cell surface receptor components remains enigmatic. Recombinant human VpreB protein was used to generate a ... More