In vitro analysis of LIPH mutations causing hypotrichosis simplex: evidence confirming the role of lipase H and lysophosphatidic acid in hair growth.
AuthorsPasternack SM, von Kügelgen I, Müller M, Oji V, Traupe H, Sprecher E, Nöthen MM, Janecke AR, Betz RC,
JournalJ Invest Dermatol
PubMed ID19536142
'Hypotrichosis simplex (HS) is a group of isolated alopecias that can be inherited as an autosomal-dominant or an autosomal-recessive trait. Hair loss usually begins in early childhood, and is diffuse and progressive. Mutations in LIPH, which encodes lipase member H, have recently been shown to cause an autosomal-recessive form of ... More
A novel fluorogenic substrate for the measurement of endothelial lipase activity.
'Endothelial lipase (EL) is a phospholipase A1 (PLA1) enzyme that hydrolyzes phospholipids at the sn-1 position to produce lysophospholipids and free fatty acids. Measurement of the PLA1 activity of EL is usually accomplished by the use of substrates that are also hydrolyzed by lipases in other subfamilies such as PLA2 ... More
Activation of a bacterial virulence protein by the GTPase RhoA.
AuthorsChristen M, Coye LH, Hontz JS, LaRock DL, Pfuetzner RA, Megha, Miller SI,
JournalSci Signal
PubMed ID19887681
The Rho family of guanosine triphosphatases (GTPases) are essential eukaryotic signaling molecules that regulate cellular physiology. Virulence factors from various pathogens alter the signaling of GTPases by acting as GTPase activating factors, guanine nucleotide exchange factors, or direct covalent modifiers; however, bacterial virulence factors that sense rather than alter the ... More
Loss-of-function variants in C3ORF52 result in localized autosomal recessive hypotrichosis.
Authors
JournalGenet Med
PubMed ID32336749
Structural, mechanistic, and physiological insights into phospholipase A-mediated membrane phospholipid degradation in Pseudomonas aeruginosa.
Authors
JournalElife
PubMed ID35536643
Identification of pluripotent cells in bovine uterus: in situ and in vitro studies.
Authors
JournalReproduction
PubMed ID25556182
Character comparison of abdomen-derived and eyelid-derived mesenchymal stem cells.