Analysis and optimization of copper-catalyzed azide-alkyne cycloaddition for bioconjugation.
AuthorsHong V, Presolski SI, Ma C, Finn MG,
JournalAngew Chem Int Ed Engl
PubMed ID19943299
Since its discovery in 2002, the copper-catalyzed azide-alkyne cycloaddition (CuAAC) reaction—the most widely recognized example of click chemistry—has been rapidly embraced for applications in myriad fields. The attractiveness of this procedure stems from the selective reactivity of azides and alkynes only with each other. Because of the fragile nature and ... More