AuthorsSato-Nishiuchi R, Nakano I, Ozawa A, Sato Y, Takeichi M, Kiyozumi D, Yamazaki K, Yasunaga T, Futaki S, Sekiguchi K,
JournalJ Biol Chem
PubMed ID22654117
'A variety of proteins, including tenascin-C and osteopontin, have been identified as ligands for integrin a9ß1. However, their affinities for integrin a9ß1 are apparently much lower than those of other integrins (e.g. a3ß1, a5ß1, and a8ß1) for their specific ligands, leaving the possibility that physiological ligands for integrin a9ß1 still ... More
Low-density Lipoprotein Receptor-related Protein-1 (LRP1) Mediates Autophagy and Apoptosis Caused by Helicobacter pylori VacA.
AuthorsYahiro K, Satoh M, Nakano M, Hisatsune J, Isomoto H, Sap J, Suzuki H, Nomura F, Noda M, Moss J, Hirayama T,
JournalJ Biol Chem
PubMed ID22822085
In Helicobacter pylori infection, vacuolating cytotoxin (VacA)-induced mitochondrial damage leading to apoptosis is believed to be a major cause of cell death. It has also been proposed that VacA-induced autophagy serves as a host mechanism to limit toxin-induced cellular damage. Apoptosis and autophagy are two dynamic and opposing processes that ... More