Rolling on E- or P-selectin induces the extended but not high-affinity conformation of LFA-1 in neutrophils.
AuthorsKuwano Y, Spelten O, Zhang H, Ley K, Zarbock A,
JournalBlood
PubMed ID20445017
'Human blood neutrophils rolling on E- or P-selectin reduced their rolling velocity when intercellular adhesion molecule (ICAM)-1 was available. Similar to mouse neutrophils, this was dependent on P-selectin glycoprotein ligand 1 (PSGL1), alpha(L)beta(2) integrin, the Src family tyrosine kinase FGR and spleen tyrosine kinase SYK. Blocking phospholipase C or p38 ... More