Succinate secreted by Trypanosoma brucei is produced by a novel and unique glycosomal enzyme, NADH-dependent fumarate reductase.
AuthorsBesteiro S, Biran M, Biteau N, Coustou V, Baltz T, Canioni P, Bringaud F
JournalJ Biol Chem
PubMed ID12138089
In all trypanosomatids, including Trypanosoma brucei, glycolysis takes place in peroxisome-like organelles called glycosomes. These are closed compartments wherein the energy and redox (NAD(+)/NADH) balances need to be maintained. We have characterized a T. brucei gene called FRDg encoding a protein 35% identical to Saccharomyces cerevisiae fumarate reductases. Microsequencing of ... More
The C-type lectin receptor Endo180 displays internalization and recycling properties distinct from other members of the mannose receptor family.
AuthorsHoward Matthew J; Isacke Clare M;
JournalJ Biol Chem
PubMed ID12068012
Endo180/urokinase plasminogen activator receptor-associated protein together with the mannose receptor, the phospholipase A(2) receptor, and DEC-205/MR6-gp200 comprise the four members of the mannose receptor family. These receptors have a unique structural composition due to the presence of multiple C-type lectin-like domains within a single polypeptide backbone. In addition, they are ... More