Androgen receptor signaling: mechanism of interleukin-6 inhibition.
AuthorsJia L, Choong CS, Ricciardelli C, Kim J, Tilley WD, Coetzee GA
JournalCancer Res
PubMed ID15059919
Nonsteroidal signaling via the androgen receptor (AR) plays an im-portant role in hormone-refractory prostate cancer. Previously, we have reported that the pleiotropic cytokine, interleukin (IL)-6, inhibited dihydrotestosterone-mediated expression of prostate-specific antigen in LNCaP cells (Jia et al., Mol Can Res 2003;1:385-92). In the present study, we explored the mechanisms involved ... More