Apical localization of wingless transcripts is required for wingless signaling.
AuthorsSimmonds AJ, dosSantos G, Livne-Bar I, Krause HM
JournalCell
PubMed ID11336670
'Many developing and adult tissues are comprised of polarized epithelia. Proteins that are asymmetrically distributed in these cells are thought to be localized by protein trafficking. Here we show that the distribution and function of the signaling protein Wingless is predetermined by the subcellular localization of its mRNA. High-resolution in ... More
The alpha(IIb)beta(3) integrin and GPIb-V-IX complex identify distinct stages in the maturation of CD34(+) cord blood cells to megakaryocytes.
AuthorsLepage A, Leboeuf M, Cazenave JP, de la Salle C, Lanza F, Uzan G
JournalBlood
PubMed ID11110688
Megakaryocytopoiesis is a complex multistep process involving cell division, endoreplication, and maturation and resulting in the release of platelets into the blood circulation. Megakaryocytes (MK) progressively express lineage-restricted proteins, some of which play essential roles in platelet physiology. Glycoprotein (GP)Ib-V-IX (CD42) and GPIIb (CD41) are examples of MK-specific proteins having ... More