Role of Nrf2 and protective effects of Metformin against tobacco smoke-induced cerebrovascular toxicity.
AuthorsPrasad S, Sajja RK, Kaisar MA, Park JH, Villalba H, Liles T, Abbruscato T, Cucullo L
JournalRedox Biol
PubMed ID28212524
Cigarette smoking (CS) is associated with vascular endothelial dysfunction in a causative way primarily related to the TS content of reactive oxygen species (ROS), nicotine, and inflammation. TS promotes glucose intolerance and increases the risk of developing type-2 diabetes mellitus (2DM) with which it shares other pathogenic traits including the ... More