Transmission of cell stress from endoplasmic reticulum to mitochondria: enhanced expression of Lon protease.
AuthorsHori O, Ichinoda F, Tamatani T, Yamaguchi A, Sato N, Ozawa K, Kitao Y, Miyazaki M, Harding HP, Ron D, Tohyama M, M Stern D, Ogawa S
JournalJ Cell Biol
PubMed ID12082077
'The rat homologue of a mitochondrial ATP-dependent protease Lon was cloned from cultured astrocytes exposed to hypoxia. Expression of Lon was enhanced in vitro by hypoxia or ER stress, and in vivo by brain ischemia. These observations suggested that changes in nuclear gene expression (Lon) triggered by ER stress had ... More
Functional constraints of nuclear-mitochondrial DNA interactions in xenomitochondrial rodent cell lines.
AuthorsDey R, Barrientos A, Moraes CT
JournalJ Biol Chem
PubMed ID10908562
'The co-evolution of nuclear and mitochondrial genomes in vertebrates led to more than 100 specific interactions that are crucial for an optimized ATP generation. These interactions have been examined by introducing rat mtDNA into mouse cells devoid of mitochondrial DNA (mtDNA). When mtDNA-less cells derived from the common mouse (Mus ... More