Insulin-responsive aminopeptidase trafficking in 3T3-L1 adipocytes.
AuthorsGarza LA, Birnbaum MJ
JournalJ Biol Chem
PubMed ID10644714
'The insulin-responsive aminopeptidase (IRAP/VP165/gp160) was identified originally in GLUT4-containing vesicles and shown to translocate in response to insulin, much like the glucose transporter 4 (GLUT4). This study characterizes the trafficking and kinetics of IRAP in exocytosis, endocytosis, and recycling to the membrane in 3T3-L1 adipocytes. After exposure of 3T3-L1 adipocytes ... More