VEGF gene delivery to muscle: potential role for vasculogenesis in adults.
AuthorsSpringer ML, Chen AS, Kraft PE, Bednarski M, Blau HM
JournalMol Cell
PubMed ID9844628
Constitutive expression of VEGF after implantation of genetically engineered myoblasts into non-ischemic muscle led to an increase in vascular structures. Previously, effects of VEGF delivery to adult muscle have only been reported in ischemic tissues. The resulting vascular structures were reminiscent of those formed during embryonic vasculogenesis, rather than angiogenesis, ... More