Survival and stimulation of neurite outgrowth in a serum-free culture of spiral ganglion neurons from adult mice.
AuthorsVieira M,Christensen BL,Wheeler BC,Feng AS,Kollmar R
JournalHearing research
PubMed ID17521837
Patient-derived glioblastoma organoids as real-time avatars for assessing responses to clinical CAR-T cell therapy
AuthorsMeghan Logun, Xin Wang, Yusha Sun, Stephen J Bagley, Nannan Li, Arati Desai, Daniel Y Zhang, MacLean P Nasrallah, Emily Ling-Lin Pai, Bike Su Oner, Gabriela Plesa, Donald Siegel, Zev A Binder, Guo-Li Ming, Hongjun Song, Donald M O'Rourke
JournalCell Stem Cell
PubMed ID39657679
Patient-derived tumor organoids have been leveraged for disease modeling and preclinical studies but rarely applied in real time to aid with interpretation of patient treatment responses in clinics. We recently demonstrated early efficacy signals in a first-in-human, phase 1 study of dual-targeting chimeric antigen receptor (CAR)-T cells (EGFR-IL13Rα2 CAR-T cells) ... More