Aggregated low-density lipoprotein uptake induces membrane tissue factor procoagulant activity and microparticle release in human vascular smooth muscle cells.
AuthorsLlorente-Cortés V, Otero-Viñas M, Camino-López S, Llampayas O, Badimon L
JournalCirculation
PubMed ID15238452
BACKGROUND: Tissue factor (TF) is the main initiator of the arterial blood coagulation system, and aggregated LDL (agLDL) are found in the arterial intima. Our hypothesis is that agLDL internalization by vascular smooth muscle cells (VSMCs) may trigger TF-procoagulant activity. METHODS AND RESULTS: Cultured human VSMCs were obtained from human ... More
Peroxide-induced membrane blebbing in endothelial cells associated with glutathione oxidation but not apoptosis.
Cells under oxidative stress induced by peroxides undergo functional and morphological changes, which often resemble those observed during apoptosis. Peroxides, however, also cause the oxidation of intracellular reduced glutathione (GSH). We investigated the relation between these peroxide-induced effects by using human umbilical vein endothelial cells (HUVEC) and two HUVEC-derived cell ... More