AuthorsGonzalez-Villalobos R, Klassen RB, Allen PL, Navar LG, Hammond TG,
JournalAm J Physiol Renal Physiol
PubMed ID15467006
Megalin is an abundant membrane protein heavily involved in receptor-mediated endocytosis. The major functions of megalin in vivo remain incompletely defined as megalin typically faces specialized milieus such as glomerular filtrate, airways, epididymal fluid, thyroid colloid, and yolk sac fluid, which lack many of its known ligands. In the course ... More
Novel fluorescence-based approaches for the study of biogenic amine transporter localization, activity, and regulation.
Pre-synaptic norepinephrine (NE) and dopamine (DA) transporters (NET and DAT) terminate catecholamine synaptic transmission through reuptake of released neurotransmitter. Recent studies reveal that NET and DAT are tightly regulated by receptor and second messenger-linked signaling pathways. Common approaches for studying these transporters involve use of radiolabeled substrates or antagonists, methods ... More