Anti-IL-23 antibody blockade of IL-23/IL-17 pathway attenuates airway obliteration in rat orthotopic tracheal transplantation.
AuthorsCao H, Lan Q, Shi Q, Zhou X, Liu G, Liu J, Tang G, Qiu C, Qiu C, Xu J, Fan H, Liu Z
JournalInt Immunopharmacol
PubMed ID21094688
'Obliterative bronchiolitis (OB) has been a major obstacle to long-term allograft survival after lung transplantation, and the underlying mechanism is not well understood. As IL-23/IL-17 pathway has been shown to play important roles in airway inflammation, in this study we have investigated the role of IL-23/IL-17 pathway in acute and ... More
Critical role of interleukin-17/interleukin-17 receptor axis in mediating Con A-induced hepatitis.
AuthorsYan S, Wang L, Liu N, Wang Y, Chu Y
JournalImmunol Cell Biol
PubMed ID21691280
'Concanavalin A (Con A)-induced hepatitis is thought to be a T-cell-mediated disease with active destruction of liver cells. Interleukin (IL)-17 is a cytokine produced principally by CD4(+) T cells. However, whether IL-17/IL-17 receptor (IL-17/IL-17R)-mediated responses are involved in T-cell-mediated Con A-induced liver injury remains unclear. In this study, we found ... More
Role of epithelial integrin-linked kinase in promoting intestinal inflammation: effects on CCL2, fibronectin and the T cell repertoire.
AuthorsAssi K, Patterson S, Dedhar S, Owen D, Levings M, Salh B
JournalBMC Immunol
PubMed ID21806815
The role of integrin signaling in mucosal inflammation is presently unknown. Hence, we aimed to investigate the role of epithelial-derived integrin-linked kinase (ILK), a critical integrin signaling intermediary molecule, in colonic inflammation. ... More
T cells from Programmed Death-1 deficient mice respond poorly to Mycobacterium tuberculosis infection.
AuthorsTousif S, Singh Y, Prasad DV, Sharma P, Van Kaer L, Das G
JournalPLoS One
PubMed ID21589883
Programmed Death-1 (PD-1; CD279) receptor molecule is widely believed to be a negative regulator predominantly expressed by exhausted/activated mouse T cells. Upon interaction with its ligands, PD-L1 and PD-L2, PD-1 inhibits activation of T cells and cytokine production, which has been documented in various viral and fungal infections as well ... More
A human colonic commensal promotes colon tumorigenesis via activation of T helper type 17 T cell responses.
AuthorsWu S, Rhee KJ, Albesiano E, Rabizadeh S, Wu X, Yen HR, Huso DL, Brancati FL, Wick E, McAllister F, Housseau F, Pardoll DM, Sears CL
JournalNat Med
PubMed ID19701202
The intestinal flora may promote colon tumor formation. Here we explore immunologic mechanisms of colonic carcinogenesis by a human colonic bacterium, enterotoxigenic Bacteroides fragilis (ETBF). ETBF that secretes B. fragilis toxin (BFT) causes human inflammatory diarrhea but also asymptomatically colonizes a proportion of the human population. Our results indicate that ... More
Early life exposure to lipopolysaccharide suppresses experimental autoimmune encephalomyelitis by promoting tolerogenic dendritic cells and regulatory T cells.
AuthorsEllestad KK, Tsutsui S, Noorbakhsh F, Warren KG, Yong VW, Pittman QJ, Power C
JournalJ Immunol
PubMed ID19542441
The rising incidence of autoimmune diseases such as multiple sclerosis (MS) in developed countries might be due to a more hygienic environment, particularly during early life. To investigate this concept, we developed a model of neonatal exposure to a common pathogen-associated molecular pattern, LPS, and determined its impact on experimental ... More