Eight amino acids form the ATP recognition site of Na(+)/K(+)-ATPase.
AuthorsKubala M, Teisinger J, Ettrich R, Hofbauerová K, Kopecký V, Baumruk V, Krumscheid R, Plásek J, Schoner W, Amler E
JournalBiochemistry
PubMed ID12767226
'Point mutations of a part of the H(4)-H(5) loop (Leu(354)-Ile(604)) of Na(+)/K(+)-ATPase have been used to study the ATP and TNP-ATP binding affinities. Besides the previously reported amino acid residues Lys(480), Lys(501), Gly(502), and Cys(549), we have found four more amino acid residues, viz., Glu(446), Phe(475), Gln(482), and Phe(548), completing ... More