Micron-scale coherence in interphase chromatin dynamics.
AuthorsZidovska A, Weitz DA, Mitchison TJ,
Journal
PubMed ID24019504
'Chromatin structure and dynamics control all aspects of DNA biology yet are poorly understood, especially at large length scales. We developed an approach, displacement correlation spectroscopy based on time-resolved image correlation analysis, to map chromatin dynamics simultaneously across the whole nucleus in cultured human cells. This method revealed that chromatin ... More
MDC1 directs chromosome-wide silencing of the sex chromosomes in male germ cells.
AuthorsIchijima Y, Ichijima M, Lou Z, Nussenzweig A, Camerini-Otero RD, Chen J, Andreassen PR, Namekawa SH,
JournalGenes Dev
PubMed ID21536735
Chromosome-wide inactivation is an epigenetic signature of sex chromosomes. The mechanism by which the chromosome-wide domain is recognized and gene silencing is induced remains unclear. Here we identify an essential mechanism underlying the recognition of the chromosome-wide domain in the male germline. We show that mediator of DNA damage checkpoint ... More