Chlamydia trachomatis inclusions induce asymmetric cleavage furrow formation and ingression failure in host cells.
Authors:Sun HS, Wilde A, Harrison RE,
Journal:Mol Cell Biol
PubMed ID:21969606
'Chlamydia trachomatis infection has been suggested to induce host genome duplication and is linked to increased risks of cervical cancer. We describe here the mechanism by which Chlamydia causes a cleavage furrow defect that consistently results in the formation of multinucleated host cells, a phenomenon linked to tumorigenesis. Host signaling ... More