EphrinB reverse signaling contributes to endothelial and mural cell assembly into vascular structures.
AuthorsSalvucci O, Maric D, Economopoulou M, Sakakibara S, Merlin S, Follenzi A, Tosato G,
JournalBlood
PubMed ID19411631
EphrinB transmembrane ligands and their cognate EphB receptor tyrosine kinases regulate vascular development through bidirectional cell-to-cell signaling, but little is known about the role of EphrinB during postnatal vascular remodeling. We report that EphrinB is a critical mediator of postnatal pericyte-to-endothelial cell assembly into vascular structures. This function is dependent ... More