An essential role for p120-catenin in Src- and Rac1-mediated anchorage-independent cell growth.
AuthorsDohn MR, Brown MV, Reynolds AB,
JournalJ Cell Biol
PubMed ID19188496
p120-catenin regulates epithelial cadherin stability and has been suggested to function as a tumor suppressor. In this study, we used anchorage-independent growth (AIG), a classical in vitro tumorigenicity assay, to examine the role of p120 in a different context, namely oncogene-mediated tumorigenesis. Surprisingly, p120 ablation by short hairpin RNA completely ... More