Coexpression of CD25 and CD27 identifies FoxP3+ regulatory T cells in inflamed synovia.
AuthorsRuprecht CR, Gattorno M, Ferlito F, Gregorio A, Martini A, Lanzavecchia A, Sallusto F,
JournalJ Exp Med
PubMed ID15939793
A better understanding of the role of CD4+CD25+ regulatory T cells in disease pathogenesis should follow from the discovery of reliable markers capable of discriminating regulatory from activated T cells. We report that the CD4+CD25+ population in synovial fluid of juvenile idiopathic arthritis (JIA) patients comprises both regulatory and effector ... More