Sidekicks: synaptic adhesion molecules that promote lamina-specific connectivity in the retina.
AuthorsYamagata M, Weiner JA, Sanes JR
JournalCell
PubMed ID12230981
A major determinant of specific connectivity in the central nervous system is that synapses made by distinct afferent populations are restricted to particular laminae in their target area. We identify Sidekick (Sdk)-1 and -2, homologous transmembrane immunoglobulin superfamily molecules that mediate homophilic adhesion in vitro and direct laminar targeting of ... More