Impaired neuromuscular transmission and skeletal muscle fiber necrosis in mice lacking Na/Ca exchanger 3.
AuthorsSokolow S, Manto M, Gailly P, Molgó J, Vandebrouck C, Vanderwinden JM, Herchuelz A, Schurmans S
JournalJ Clin Invest
PubMed ID14722618
'We produced and analyzed mice deficient for Na/Ca exchanger 3 (NCX3), a protein that mediates cellular Ca(2+) efflux (forward mode) or Ca(2+) influx (reverse mode) and thus controls intracellular Ca(2+) concentration. NCX3-deficient mice (Ncx3(-/-)) present a skeletal muscle fiber necrosis and a defective neuromuscular transmission, reflecting the absence of NCX3 ... More
Use of desmin immunohistochemistry to distinguish between mesothelial cells and carcinoma in serous fluid cell block preparations.
AuthorsGill SA, Meier PA, Kendall BS
JournalActa Cytol
PubMed ID11127755
OBJECTIVE: To evaluate the utility of immunohistochemical stains for desmin in discriminating mesothelial cells from adenocarcinoma in serous fluid cell block preparations. STUDY DESIGN: Cell block preparations from 22 cases (representing 18 patients) that were positive for carcinoma and 5 cases that were negative for malignancy were immunostained with an ... More
The cxc chemokine cCAF stimulates differentiation of fibroblasts into myofibroblasts and accelerates wound closure.
AuthorsFeugate JE, Li Q, Wong L, Martins-Green M
JournalJ Cell Biol
PubMed ID11781340
Chemokines are small cytokines primarily known for their roles in inflammation. More recently, however, they have been implicated in processes involved in development of the granulation tissue of wounds, but little is known about their functions during this process. Fibroblasts play key roles in this phase of healing: some fibroblasts ... More