Features of medullary thymic epithelium implicate postnatal development in maintaining epithelial heterogeneity and tissue-restricted antigen expression.
AuthorsGillard GO, Farr AG
JournalJ Immunol
PubMed ID16670287
'Although putative thymic epithelial progenitor cells have been identified, the developmental potential of these cells, the extent of medullary thymic epithelium (mTEC) heterogeneity, and the mechanisms that mediate the expression of a wide range of peripheral tissue-restricted Ags (TRAs) by mTECs remain poorly defined. Here we have defined several basic ... More
Form deprivation modulates retinal neurogenesis in primate experimental myopia.
AuthorsTkatchenko AV, Walsh PA, Tkatchenko TV, Gustincich S, Raviola E
JournalProc Natl Acad Sci U S A
PubMed ID16537371
Juvenile primates develop myopia when their visual experience is degraded by lid fusion. In response to this abnormal visual input, retinal neural networks cause an excessive growth of the postequatorial segment of the eye, but the mechanism underlying this axial elongation is unknown. After fusion of the lids in one ... More