The EphB4 receptor suppresses breast cancer cell tumorigenicity through an Abl-Crk pathway.
AuthorsNoren NK, Foos G, Hauser CA, Pasquale EB
JournalNat Cell Biol
PubMed ID16862147
'Recent evidence supports a role for EphB receptor tyrosine kinases as tumour suppressors in colorectal and prostate cancer. However, it is unclear how these receptors inhibit cancer cell tumorigenicity - an activity that is highly unusual for a family of receptor tyrosine kinases. Here, we report that the EphB4 receptor ... More
Postreplicative mismatch repair factors are recruited to Epstein-Barr virus replication compartments.
AuthorsDaikoku T, Kudoh A, Sugaya Y, Iwahori S, Shirata N, Isomura H, Tsurumi T
JournalJ Biol Chem
PubMed ID16510450
'The mismatch repair (MMR) system, highly conserved throughout evolution, corrects nucleotide mispairing that arise during cellular DNA replication. We report here that proliferating cell nuclear antigen (PCNA), the clamp loader complex (RF-C), and a series of MMR proteins like MSH-2, MSH-6, MLH1, and hPSM2 can be assembled to Epstein-Barr virus ... More
AuthorsKim HK, Lee YS, Sivaprasad U, Malhotra A, Dutta A
JournalJ Cell Biol
PubMed ID16923828
Three muscle-specific microRNAs, miR-206, -1, and -133, are induced during differentiation of C2C12 myoblasts in vitro. Transfection of miR-206 promotes differentiation despite the presence of serum, whereas inhibition of the microRNA by antisense oligonucleotide inhibits cell cycle withdrawal and differentiation, which are normally induced by serum deprivation. Among the many ... More