Rac1 inhibits myogenic differentiation by preventing the complete withdrawal of myoblasts from the cell cycle.
AuthorsHeller H, Gredinger E, Bengal E
JournalJ Biol Chem
PubMed ID11489882
'The small GTPase protein Rac1 is involved in a wide range of biological processes, yet its role in cell differentiation is mostly unknown. Here we show that Rac1 activity is high in proliferating myoblasts and decreases during the differentiation process. To analyze the involvement of Rac1 in muscle differentiation, different ... More
Cyclin D1 protein analysis in the diagnosis of mantle cell lymphoma.
Authorsde Boer CJ, Schuuring E, Dreef E, Peters G, Bartek J, Kluin PM, van Krieken JH
JournalBlood
PubMed ID7670110
'Mantle cell lymphoma (MCL) is a clinicopathologic entity that is difficult to diagnose on histopathologic criteria. Approximately 50% to 70% of MCL contain a t(11;14)(q13;q32) translocation involving the cyclin D1 gene. Irrespective of this rearrangement, almost all MCL show overexpression of the cyclin D1 gene at the mRNA level. Other ... More
Cyclin D1 protein expression and function in human breast cancer.
'Cyclin D1 is a cell-cycle regulator essential for G1 phase progression and a candidate proto-oncogene implicated in pathogenesis of several human tumour types, including breast carcinomas. In spite of the accumulating genetic evidence, however, there are no data regarding abundance and properties of the cyclin D1 protein in breast cancer. ... More
Abnormal expression of CCND1 and RB1 in resection margin epithelia of lung cancer patients.
AuthorsBetticher DC, Heighway J, Thatcher N, Hasleton PS
JournalBr J Cancer
PubMed ID9192978
'Tumours develop through the accumulation of genetic alterations associated with a progressive increase of the malignant phenotype. In lung cancer, chronic exposure of bronchial epithelium to carcinogens in cigarette smoke may lead to multiple dysplastic and hyperplastic lesions scattered throughout the tracheobronchial tree. Little is known about the genetic alterations ... More
A case of gross neonatal omphalitis in the United Kingdom.
AuthorsHalliday HL
JournalUlster Med J
PubMed ID4439541
Cyclin D1 expression in gliomas.
AuthorsCavalla P, Dutto A, Piva R, Richiardi P, Grosso R, Schiffer D
JournalActa Neuropathol (Berl)
PubMed ID9498046
Cyclin D1 (cycD1) expression was defined immunohistochemically using monoclonal antibody DCS-6 and polyclonal antiserum H-295 in 50 glioma biopsies. The number of positive nuclei was higher for H-295 than for DCS-6, with a ratio of 3:1. The labelling index (LI) was compared to the grade of histological malignancy and to ... More
Arrest of mammalian fibroblasts in G1 in response to actin inhibition is dependent on retinoblastoma pocket proteins but not on p53.
p53 and the retinoblastoma (RB) pocket proteins are central to the control of progression through the G1 phase of the cell cycle. The RB pocket protein family is downstream of p53 and controls S-phase entry. Disruption of actin assembly arrests nontransformed mammalian fibroblasts in G1. We show that this arrest ... More
The LIM-only protein FHL2 interacts with beta-catenin and promotes differentiation of mouse myoblasts.
AuthorsMartin B, Schneider R, Janetzky S, Waibler Z, Pandur P, Kühl M, Behrens J, von der Mark K, Starzinski-Powitz A, Wixler V
JournalJ Cell Biol
PubMed ID12370240
FHL2 is a LIM-domain protein expressed in myoblasts but down-regulated in malignant rhabdomyosarcoma cells, suggesting an important role of FHL2 in muscle development. To investigate the importance of FHL2 during myoblast differentiation, we performed a yeast two-hybrid screen using a cDNA library derived from myoblasts induced for differentiation. We identified ... More
The PRAD-1/cyclin D1 oncogene product accumulates aberrantly in a subset of colorectal carcinomas.
AuthorsBartkova J, Lukas J, Strauss M, Bartek J
JournalInt J Cancer
PubMed ID8056453
The PRAD-1/cyclin D1 proto-oncogene is localized on chromosome 11q13 and it is overexpressed in several tumour types as a consequence of gene amplification or chromosomal rearrangements. In this study, the abundance and patterns of cyclin D1 protein expression in normal/non-involved colon (n = 44), primary (n = 48) and metastatic ... More
Cell cycle-related variation and tissue-restricted expression of human cyclin D1 protein.
AuthorsBartkova J, Lukas J, Strauss M, Bartek J
JournalJ Pathol
PubMed ID8195927
Recent evidence from genetic studies suggests that abnormalities of some of the members of the cyclin superfamily may be intimately associated with tumourigenesis, most likely through deregulation of the cell cycle control. In an attempt to elucidate the potential role of cyclin D1 (a gene located within the 11q13 amplicon ... More
Cyclin D1 is dispensable for G1 control in retinoblastoma gene-deficient cells independently of cdk4 activity.
AuthorsLukas J, Bartkova J, Rohde M, Strauss M, Bartek J
JournalMol Cell Biol
PubMed ID7739541
To elucidate the regulator-versus-target relationship in the cyclin D1/cdk4/retinoblastoma protein (pRB) pathway, we examined fibroblasts from RB-1 gene-deficient and RB-1 wild-type littermate mouse embryos (ME) and in human tumor cell lines that differed in the status of the RB-1 gene. The RB+/+ and RB-/- ME fibroblasts expressed similar protein levels ... More
Lack of cyclin D1 overexpression in gastric carcinogenesis.
AuthorsBlok P, Craanen ME, van Diest PJ, Dekker W, Tytgat GN
JournalHistopathology
PubMed ID10672060
AIMS: Cyclin D1 overexpression was examined in early gastric carcinomas and precursor lesions with the following aims; (1) to assess the chronology of cyclin D1 overexpression in various stages of gastric carcinogenesis, (2) to correlate cyclin D1 overexpression with the Lauren type, the grade of differentiation and the type of ... More