Regulation of cytochrome c oxidase activity by c-Src in osteoclasts.
AuthorsMiyazaki T, Neff L, Tanaka S, Horne WC, Baron R
JournalJ Cell Biol
PubMed ID12615910
The function of the nonreceptor tyrosine kinase c-Src as a plasma membrane-associated molecular effector of a variety of extracellular stimuli is well known. Here, we show that c-Src is also present within mitochondria, where it phosphorylates cytochrome c oxidase (Cox). Deleting the c-src gene reduces Cox activity, and this inhibitory ... More
Biochemical, genetic and immunoblot analyses of 17 patients with an isolated cytochrome c oxidase deficiency.
Authorsvon Kleist-Retzow JC, Vial E, Chantrel-Groussard K, Rötig A, Munnich A, Rustin P, Taanman JW
JournalBiochim Biophys Acta
PubMed ID10524227
Mitochondrial respiratory chain defects involving cytochrome c oxidase (COX) are found in a clinically heterogeneous group of diseases, yet the molecular basis of these disorders have been determined in only a limited number of cases. Here, we report the clinical, biochemical and molecular findings in 17 patients who all had ... More
Cytochrome C oxidase activity and oxygen tolerance.
AuthorsCampian JL, Gao X, Qian M, Eaton JW
JournalJ Biol Chem
PubMed ID17303578
Most cultured cells and intact animals die under hyperoxic conditions. However, a strain of HeLa cells that proliferates under 80% O(2), termed "HeLa-80," has been derived from wildtype HeLa cells ("HeLa-20") by selection for resistance to stepwise increases of oxygen partial pressure. The tolerance of HeLa-80 cells to hyperoxia is ... More