Modulation of antigen presentation by autoreactive B cell clones specific for GAD65 from a type I diabetic patient.
AuthorsBanga JP, Moore JK, Duhindan N, Madec AM, van Endert PM, Orgiazzi J, Endl J
JournalClin Exp Immunol
PubMed ID14678267
We used a GAD65-specific human B-T cell line cognate system in vitro to investigate the modulation of GAD65 presentation by autoantibody, assessed in a proliferation assay. Generally, if the T cell determinant overlaps or resides within the antibody epitope, effects of presentation are blunted while if they are distant can ... More