Induction of Id1 and Id3 by latent membrane protein 1 of Epstein-Barr virus and regulation of p27/Kip and cyclin-dependent kinase 2 in rodent fibroblast transformation.
AuthorsEverly DN, Mainou BA, Raab-Traub N
JournalJ Virol
PubMed ID15564458
Latent membrane protein 1 (LMP1), the Epstein-Barr virus oncoprotein, activates NF-kappaB, phosphatidylinositol 3-kinase, mitogen-activated protein kinase, and c-Jun N-terminal kinase signaling. To determine global transcriptional changes induced by LMP1 in epithelial cells, genomic analysis of C33A cells stably expressing LMP1 was performed. Relatively few genes were induced by LMP1. Expression ... More
Effects of rottlerin on silica-exacerbated systemic autoimmune disease in New Zealand mixed mice.
AuthorsBrown JM, Schwanke CM, Pershouse MA, Pfau JC, Holian A,
JournalAm J Physiol Lung Cell Mol Physiol
PubMed ID16040631
'Environmental crystalline silica exposure has been associated with formation of autoantibodies and development of systemic autoimmune disease, but the mechanisms leading to these events are unknown. Silica exposure in autoimmune-prone New Zealand mixed (NZM) mice results in a significant exacerbation of systemic autoimmunity as measured by increases in autoantibodies and ... More
PLRG1 is an essential regulator of cell proliferation and apoptosis during vertebrate development and tissue homeostasis.
AuthorsKleinridders A, Pogoda HM, Irlenbusch S, Smyth N, Koncz C, Hammerschmidt M, Brüning JC,
JournalMol Cell Biol
PubMed ID19307306
'PLRG1, an evolutionarily conserved component of the spliceosome, forms a complex with Pso4/SNEV/Prp19 and the cell division and cycle 5 homolog (CDC5L) that is involved in both pre-mRNA splicing and DNA repair. Here, we show that the inactivation of PLRG1 in mice results in embryonic lethality at 1.5 days postfertilization. ... More
Defects in lamin B1 expression or processing affect interphase chromosome position and gene expression.
AuthorsMalhas A, Lee CF, Sanders R, Saunders NJ, Vaux DJ,
JournalJ Cell Biol
PubMed ID17312019
Radial organization of nuclei with peripheral gene-poor chromosomes and central gene-rich chromosomes is common and could depend on the nuclear boundary as a scaffold or position marker. To test this, we studied the role of the ubiquitous nuclear envelope (NE) component lamin B1 in NE stability, chromosome territory position, and ... More