'Certain types of intracellular organelle transport to the cell periphery are thought to involve long-range movement on microtubules by kinesin with subsequent handoff to vertebrate myosin Va (myoVa) for local delivery on actin tracks. This process may involve direct interactions between these two processive motors. Here we demonstrate using single ... More
Sidekicks: synaptic adhesion molecules that promote lamina-specific connectivity in the retina.
AuthorsYamagata M, Weiner JA, Sanes JR
JournalCell
PubMed ID12230981
A major determinant of specific connectivity in the central nervous system is that synapses made by distinct afferent populations are restricted to particular laminae in their target area. We identify Sidekick (Sdk)-1 and -2, homologous transmembrane immunoglobulin superfamily molecules that mediate homophilic adhesion in vitro and direct laminar targeting of ... More
Two distinct distributions of F-actin are present in the hyphal apex of the oomycete Achlya bisexualis.
AuthorsYu YP, Jackson SL, Garrill A
JournalPlant Cell Physiol
PubMed ID15047875
We show that two distinct distributions of F-actin are present in the hyphal apex of the oomycete Achlya bisexualis, that have been chemically fixed with a combination of methylglyoxal and formaldehyde and stained with Alexa phalloidin. In approximately one half of the hyphae examined, an F-actin depleted zone within the ... More
A role for PKC-epsilon in Fc gammaR-mediated phagocytosis by RAW 264.7 cells.
AuthorsLarsen EC, Ueyama T, Brannock PM, Shirai Y, Saito N, Larsson C, Loegering D, Weber PB, Lennartz MR
JournalJ Cell Biol
PubMed ID12499353
Protein kinase C (PKC) plays a prominent role in immune signaling, and the paradigms for isoform selective signaling are beginning to be elucidated. Real-time microscopy was combined with molecular and biochemical approaches to demonstrate a role for PKC- epsilon in Fc gamma receptor (Fc gammaR)-dependent phagocytosis. RAW 264.7 macrophages were ... More
The HIV-1 pathogenicity factor Nef interferes with maturation of stimulatory T-lymphocyte contacts by modulation of N-Wasp activity.
AuthorsHaller C, Rauch S, Michel N, Hannemann S, Lehmann MJ, Keppler OT, Fackler OT
JournalJ Biol Chem
PubMed ID16687395
The Nef protein is a key determinant of human immunodeficiency virus (HIV) pathogenicity that, among other activities, sensitizes T-lymphocytes for optimal virus production. The initial events by which Nef modulates the T-cell receptor (TCR) cascade are poorly understood. TCR engagement triggers actin rearrangements that control receptor clustering for signal initiation ... More
A memory of eS25 loss drives resistance phenotypes.
Authors
JournalNucleic Acids Res
PubMed ID32463448
Scleraxis is required for differentiation of the stapedius and tensor tympani tendons of the middle ear.
Authors
JournalJ Assoc Res Otolaryngol
PubMed ID21399989
Relative importance of βcyto- and γcyto-actin in primary mouse embryonic fibroblasts.
Authors
JournalMol Biol Cell
PubMed ID28077619
Functional auditory hair cells produced in the mammalian cochlea by in utero gene transfer.
Authors
JournalNature
PubMed ID18754012
Characterisation of maturation of photoreceptor cell subtypes during zebrafish retinal development.
Authors
JournalBiol Open
PubMed ID30237290
Cathelicidins Mitigate Staphylococcus aureus Mastitis and Reduce Bacterial Invasion in Murine Mammary Epithelium.
Authors
JournalInfect Immun
PubMed ID32341117
Autocrine signaling is a key regulatory element during osteoclastogenesis.
Authors
JournalBiol Open
PubMed ID25063197
Apico-basal cell compression regulates Lamin A/C levels in epithelial tissues.
Authors
JournalNat Commun
PubMed ID33767161
Controlling the polarity of human gastrointestinal organoids to investigate epithelial biology and infectious diseases.
Authors
JournalNat Protoc
PubMed ID34663962
Direct binding of polymeric GBP1 to LPS disrupts bacterial cell envelope functions.