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Invitrogen
Human CDK13/cyclin K, GST Tag, His Tag Recombinant Protein
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产品信息
A33732
产品规格
种属
Human
Expression System
Insect cells
氨基酸序列
CDK13: 656 -1050, Cyclin K: 1-300
标签
GST-tag, His-tag
分子量
73.8-63.0 kDa
分类
Recombinant
类型
Protein
偶联物
形式
Liquid
浓度
See Label
纯化类型
purified
保存液
50mM HEPES, pH 7.5, with 5mM DTT, 100mM NaCl, 15mM glutathione, 20% glycerol
内含物
no preservative
保存条件
-80°C, Avoid Freeze/Thaw Cycles
运输条件
Dry ice
产品详细信息
For maximum recovery please spin prior to use. Unless noted below, aliquots of the 5 µg, 10 µg and 20 µg sizes of kinase are not recommended as materials can be used in original packaging until exhausted. For larger sizes, the number of freeze/thaws may be reduced by preparing aliquots, aliquots below 20 µL are not recommended. Please never store a kinase diluted. If properly stored at -80C, this product is guaranteed for 6 months from date of purchase.
This CDK13/cyclin K recombinant human protein (CDK13: 656-1050, cyclin K 1-300) was expressed in insect cells.
CDK13/cyclin K recombinant human protein is also available in our SelectScreen™ Kinase Profiling Service.
• Validated for use with the LanthaScreen™ Eu Kinase Binding assay
• Available in multiple pack sizes for convenient use
• Also available in our SelectScreen Kinase Profiling Service
Protein Form: Recombinant, Active, Catalytic
The gene accession number for CDK13 and cyclin K are NP_003709.3 and NP_001092872.1.
靶标信息
Cyclin-dependent kinase 13 (CDK13) and Cyclin K form a complex that is integral to RNA processing and transcription regulation. CDK13, a member of the CDK family, is involved in the modulation of gene expression through phosphorylation of the C-terminal domain of RNA Polymerase II, affecting the transcription elongation phase. Cyclin K acts as a regulatory partner to CDK13, stabilizing its active conformation to efficiently catalyze its kinase functions. CDK13, along with Cyclin K, plays a pivotal role in RNA metabolism, influencing RNA splicing and 3' end processing, which are crucial for the synthesis of mature mRNA. Structural studies have characterized CDK13 as having unique features differentiating it from other CDKs, including distinctive domain arrangements that enable interaction with Cyclin K. The dysregulation of CDK13/Cyclin K activity has been observed in various diseases, including cancer, pointing to their importance as therapeutic targets. Research also highlights CDK13's involvement in maintaining cellular homeostasis, underscoring the complex network of interactions this kinase engages in beyond transcriptional control.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: CDC2-related protein kinase 5; Cell division cycle 2-like protein kinase 5; Cell division protein kinase 13; Cholinesterase-related cell division controller; Cyclin-dependent kinase 13; Cyclin-K; hCDK13
基因别名: CCNK; CDC2L; CDC2L5; CDK13; CHED; CPR4; hCDK13; KIAA1791
UniProt ID: (Human) O75909, (Human) Q14004
Entrez Gene ID: (Human) 8812, (Human) 8621
