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Invitrogen
Human CDK11/cyclin C, GST Tag, His Tag Recombinant Protein
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产品信息
A33733
产品规格
种属
Human
Expression System
Insect cells
氨基酸序列
CDK11: 1-502, Cyclin C: 1-283
标签
GST-tag, His-tag
分子量
84.9-38.0 kDa
分类
Recombinant
类型
Protein
偶联物
形式
Liquid
浓度
See Label
纯化类型
purified
保存液
50mM HEPES, pH 7.5, with 20% glycerol, 5mM DTT, 100mM NaCl
内含物
no preservative
保存条件
-80°C, Avoid Freeze/Thaw Cycles
运输条件
Dry ice
产品详细信息
For maximum recovery please spin prior to use. Unless noted below, aliquots of the 5 µg, 10 µg and 20 µg sizes of kinase are not recommended as materials can be used in original packaging until exhausted. For larger sizes, the number of freeze/thaws may be reduced by preparing aliquots, aliquots below 20 µL are not recommended. Please never store a kinase diluted. If properly stored at -80C, this product is guaranteed for 6 months from date of purchase.
This CDK11/cyclin C recombinant human protein (CDK11: 1-502, cyclin C: 1-283) was expressed in insect cells.
CDK11/cyclin C recombinant human protein is also available in our SelectScreen™ Kinase Profiling Service.
• Validated for use with the LanthaScreen™ Eu Kinase Binding assay
• Available in multiple pack sizes for convenient use
• Also available in our SelectScreen Kinase Profiling Service
Protein Form: Recombinant, Active, Catalytic
The gene accession number for CDK11 and cyclin C are NP_055891.1 and NP_005181.2.
靶标信息
Cyclin-dependent kinase 11 (CDK11, and also known as CDK19) and Cyclin C are key players in regulating transcription and cell cycle progression, particularly during apoptosis and cytokinesis. CDK11 exists in two major isoforms, CDK11p46 and CDK11p110, which are generated through alternative splicing and proteolytic processing. Cyclin C partners specifically with the CDK11p46 isoform, forming a complex that is involved in RNA splicing and mediating transcriptional responses necessary for cellular stress responses. CDK11's gene is located on human chromosome 1p36.3-p36.33 and its role in mediating cytokinesis involves phosphorylation of proteins that control the breakdown of the nuclear matrix and spindle formation. Cyclin C, when associated with CDK11, has been shown to have roles in the regulation of transcription factor activity, impacting the transcriptional program during cell cycle checkpoints. Aberrant expression and functioning of the CDK11/Cyclin C complex have been implicated in tumorigenesis, highlighting its importance in cancer biology. Furthermore, CDK11 is essential for maintaining mitochondrial integrity and function, thus further broadening its influence on cellular health beyond mere transcriptional control.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: CDC2-related protein kinase 6; CDK8-like cyclin-dependent kinase; cell division cycle 2-like 6 (CDK8-like); Cell division cycle 2-like protein kinase 6; Cell division protein kinase 19; cyclin dependent kinase 19 variant 2; Cyclin-C; cyclin-dependent kinase (CDC2-like) 11; Cyclin-dependent kinase 11; Cyclin-dependent kinase 19; Death-preventing kinase; hSRB11; SRB11 homolog
基因别名: bA346C16.3; CCNC; CDC2L6; CDK11; CDK19; CycC; KIAA1028
UniProt ID: (Human) P24863, (Human) Q9BWU1
Entrez Gene ID: (Human) 892, (Human) 23097
